Monday, 18th November 4th Metabolic Diseases; Breakthrough Discoveries in Diabetes & Obesity Meeting 2024

• Dissecting the foundation of Insulin Resistance - David James
• Phosphoproteomics of bone identifies a novel mechanism of transcriptional defects in ageing and insulin resistance - Benjamin Parker
• Adipocyte cell cycle activation in obesity and hyperinsulinemia - Kirsty Spalding
• Intestinal ceramide metabolism and metabolic health  - Sarah M Turpin-Nolan
• Therapeutic knockdown of MLKL reduces diet-induced obesity and promotes insulin sensitivity. - Denuja Karunakaran

• Development and dynamics of beige fat - Paul Cohen
• The multifaceted roles of mitochondria in energy metabolism - Aleksandra Filipovska
• Targeting energy expenditure to preserve lean mass with weight loss - Kyle Hoehn
• Non-shivering thermogenesis in muscle rather than brown fat could counteract obesity - Jan Kopecky
• Unveiling the physiological function of the mitochondrial peptidase miPEP across metabolic tissues - Alexis R Diaz Vegas

Emilia Tarland
Animal scientist/behaviouralist, Sales Director Nordic Region at TSE Systems

In this presentation, we will explore cutting-edge methods to revolutionize your rodent metabolic phenotyping studies. We'll delve into powerful new techniques such as isotope tracing, assessment of microbial activity and voluntary weightlifting training.

• When a calorie is not just a calorie: The regulation of health and longevity by dietary amino acids - Dudley Lamming
• Impacts of meal timing upon the circadian regulation of glucose metabolism - Leonie Heilbronn
• All the rAGE: Impacts on glucose homeostasis and inflammation. - Josephine Forbes
• Unraveling cysteine deficiency-associated rapid weight loss - Alan Varghese

• Cachexia and wasting syndromes: insights from our microbial world - Janelle Ayres

• p300/CBP are critical for skeletal muscle GLUT4 expression - Mark Hargreaves
• Accurate assessment of the inhibition of human carbohydrate digestion and intestinal glucose transport by dietary (poly)phenols. - Michael J Houghton
• The Role of Hunger Sensing and Signalling in Motivation, Extinction and Reversal Learning. - Jiachen Hu
• Early postnatal leptin surge predicts adipose tissue accumulation in mice - Petra Janovska
• TRPM8 is a potential therapeutic target for obesity and diabetes. - Xiangjun Jin
• TMEM161B deletion induces rapid loss of fat: exploring its role in adipocyte metabolism - Stacey N Keenan
• Mechanisms of hyperinsulinemia in healthy young adults with normal glucose tolerance - Vicky Kuriel
• Sex-specific regulation of metabolism by leptin - Nicola Lee
• Characterising how an inter-organelle biogenesis network regulates mitochondrial structure and metabolism - Richard G Lee
• Glutamatergic dysfunction in dorsal striatum underlies compulsive eating in an animal model of binge eating - Yan Li
• Hypothalamic neurons expressing the relaxin receptor, orchestrate feeding behaviour and glycaemic control for metabolic disease remission in mice - Sam Mohammed
• Investigating the neural correlates of stress-induced binge eating in binge prone versus binge resistant female mice. - Mia J O'Shea
• Acute stress regulates AgRP neuronal activity - Alexander Reichenbach
• Does acute social isolation affect behaviour and metabolic characteristics of C57BL/6 mice? - Steve Risis
• Dual A1 and A2A adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, effectively modulate hepatic glucose production, suppresses intestinal postprandial glucose, and attenuates hyperglycaemia in fructose-streptozotocin diabetic rats - Olakunle O Sanni
• Comparative analysis of 15 mitochondrial uncouplers reveals diverse phenotypes in cells and mice - Divya P Shah
• Paracrine redox signalling activates T cells to promote NASH and HCC in obesity - Sumit Sheoran
• Complete Genetic Ablation of both Acetyl-CoA Carboxylase Enzymes in the Liver Exacerbates Diethylnitrosamine-Induced Hepatocellular Carcinogenesis in Female C57BL/6 Mice - Riya Shrestha
• Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity - Wang Lok So
• Identification of a GxE health variant that protects against metabolic disease - Jacqueline Stoeckli
• Neurobehavioral determinants of diet-induced obesity - Christina CS Suhartono
• Exploring the effects of intermittent fasting plus early time-restricted eating versus calorie restriction and standard care on systemic and adipose tissue markers of inflammation in adults at risk of type 2 diabetes - Laurent Turner
• Assessment of Self-Monitoring of Blood Pressure KAP (Knowledge, Attitude, Practice) Among Hypertensive Patients and Physicians' Adoption of it in their Practice 2023 - Hisham Al-Shaikhli
• Garlic extract promotes pancreatic islet neogenesis through α- to β-cell transdifferentiation and restores islet architecture in recovering diabetic rats - Amani Aladsani
• Effect of Ginger extract treatment on MAFA gene Expression in STZ-induced diabetic rats - Soaad B Alfaqaan
• Impact of short- and long- term High-fat diet on hypothalamic lipid metabolism - Adelaide Bernard
• Calorie restriction for longevity and skeletal muscle health – the role of fasting and biological sex - Amanda E Brandon
• High fat diet-driven changes in the gastrointestinal mucosal landscape are dependent on gut microbiota - Jessica Chao
• Decoding the neurobiological drivers of compulsive exercise in anorexia nervosa - Kyna Conn
• Single-cell and spatial transcriptomics identify a role for redox crosstalk in the inflammatory processes underlying human MASH. - Eamon Coughlan
• Cross tissue analysis of cardiometabolic function - Harry Cutler
• The Role of Neuronal Mitochondrial OXPHOS in Regulating Energy and Glucose Metabolism - Yi Wang
• Optimising the use of Dual-Energy X-Ray Absorptiometry to evaluate lean and fat mass loss in cancer cachexia.  - Abigail C Wust
• Hepatic glucagon function in obesity and type 2 diabetes insights from mouse models - Yuqin Wu
• Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis - Julian Wong
• Identification of APBB2 as a novel target for metabolic dysfunction-associated steatotic liver disease - Jie Lu
• Identification of INPP1 as a novel regulator of hepatic lipid metabolism - Zhili Cheng
• Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism - Romana Stark