Tuesday, 19th November 4th Metabolic Diseases; Breakthrough Discoveries in Diabetes & Obesity Meeting 2024

• Exercise-induced muscle redox profile and its relation to insulin sensitivity - Erik Richter
• Is exercise medicine? Role of exercise derived extracellular vesicles in prevention of obesity related diseases - Mark Febbraio
• The molecular landscape of exercise and ageing in human muscle through multi-omics integration  - Nir Eynon
• Phosphoinositide-driven lysosome recycling is essential for muscle glycogen metabolism - Meagan McGrath

• Control of ingestion by the caudal brainstem - Zachary Knight
• Neural hunger-sensing affects more than appetite: A role for learning. - Zane Andrews
• Effects of weight loss treatments and opioids on hypothalamic neurons - Yeka Aponte
• A Harmonized Neuroendocrine Network Orchestrating Metabolic Adaptation in the Hypothalamus - Garron T Dodd
• Role of astrocyte mpc1 in cellular and systemic energy metabolism - Jochen Schmid

We’ve set aside a lunch session to meet with some of the amazing national and international invited speakers from this year’s meeting. It will be a fantastic opportunity to engage, ask questions and have intimate one on one conversations with highly regarded professionals.

• Brainstem and Hypothalamic circuits that control feeding - Martin Myers

• APOCII gene variant analysis in a sample of Kuwaiti's with dyslipidemia - Suzanne A Al-Bustan
• ACE2 activation by Xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats - Hisham Al-Shaikhli
• Translational mechanisms underlying loss of GPR75 and protection from obesity in mice and humans - Judith Altarejos
• Mitochondrial uncoupler MB3 improves liver steatosis and promotes gut microbiota remodeling in a mouse model of non-alcoholic steatohepatitis. - Martina Beretta
• Identification of novel protein ZC3HAV1 in regulating hepatic lipid metabolism in mice - Cooper T Bowring
• Identifying Novel C-peptide Specific TCRs For The Development of Antigen-Specific T-Regulatory Cell Therapy for Type 1 Diabetes - Ashraf AB Broury
• Prevalence of obesity among hospital inpatients: a comparison of body mass index and administrative documentation in a tertiary Australian Hospital - Anna Cunliffe
• Microfibril associated protein 4 (MFAP4) – a 2-for-1 target for MASLD and obesity? - William De Nardo
• The role of a cortico-hypothalamic pathway on hunger and metabolism. - Vasilios Drakopoulos
• Arcuate nucleus POMC neurons express receptors for the anterior pituitary hormone prolactin - Chenyun Fang
• Lipid metabolism-focused CRISPR screen identifies NUS1 as essential for prostate cancer growth - Gio Fidelito
• Deep Learning Uncovers Links Between Adipose Depots and Metabolic Health in Genetically Diverse Mice - Oli K. Fuller
• Reversing GLP-1R Agonist Resistance to Turbocharge Metabolic Disease Treatment - Callen C Goldsmith
• Sex as a variable in the phenotypes of GLP-1R and GIPR knockout mice - Seungmin Ham
• Overexpression of ACAD10 alters the insulin signaling pathway and activates Gdf-15.   - Darren Henstridge
• The role of olfaction in the sensory control of AgRP neurons - Jiaxin Huang
• GLP1R agonism suppresses nucleus accumbens dopamine release and food intake - Lotus Jeffs
• The relative role of NOX4 versus NOX5 in renal complications of diabetes - Jay Jha
• A single dose of psilocybin increases susceptibility to diet-induced weight loss in obese mice - Ryan J Keenan
• Mechanistic insights into postprandial insulin-glucagon interactions and their impact on glycaemic excursions following protein-glucose co-ingestion in humans - Giang M Dao
• Phosphoinositide-driven lysosome recycling is essential for muscle glycogen metabolism - KAIQIN LE
• Targeting metabolism to overcome enzalutamide resistance in prostate cancer   - Olivia Lee
• Ablation of GFRAL neurons improves cachexia and reduces cancer burden in a mouse model of pancreatic cancer - Sarah H Lockie
• Regulation of Pancreatic Beta-Cell Function by Salt-Inducible Kinases.   - Kim Loh
• Genetic mapping of insulin sensitivity identifies alpha-defensin peptides as modulators of murine metabolic health. - Stewart WC Masson
• Quantitative interactome mapping of skeletal muscle insulin resistance to probe dynamic changes in protein:protein interactions. - Yaan Ng
• Characterising the hypothalamic secretome in metabolic disease using microdialysis and peptidogenomics - Linda T Nguyen
• A Novel Inhibitory Role for the AMPKγ3 NH₂-Terminal Extension - Ashley J. Ovens
• Differential striatal gene expression profiles underlying the propensity for depression-like behaviour in a mouse model of vertical sleeve gastrectomy - Renee A Papaluca
• Effect of β-catenin deletion in the paraventricular nucleus of the hypothalamus: differential impacts on body weight and glucose metabolism in mice - Mohammed Rizwan
• Changes in the exo-loop residue T107 alters the activity and function of Glyoxalase 1  - Carlos J Rosado
• Hepatic dynamin-related protein 1 silencing affects glucose metabolism through reduced glucose production independent of sex and body weight. - Patricia Rusu
• Targeting Calcium Signaling Pathways in Cellular Senescence - VIJAYRAGHAVAN SESHADRI
• Nutrient specific modulation of insulin action and skeletal muscle signalling pathways - Chris S Shaw
• Targeting neurofibrosis to potentiate incretin therapies - Feiyue Shi
• Female mice exhibit reduced hallmarks of metabolic dysfunction-associated steatohepatitis (MASH) than males in the GAN-DIO preclinical model of MASH. - Isabella A. Simon
• Phosphorylation-Mediated Degradation of HSD17β11 Regulates Lipolysis. - Natasha D Suriani
• Reactive gliosis of hypothalamic astrocytes drives neurofibrosis and metabolic dysfunction - Rui Qi Teo
• Phosphoproteomics-directed manipulation reveals SEC22B as an hepatic signalling node governing metabolic actions of glucagon - Adam Rose
• Interrogating the therapeutic potential of Hexosaminidase A in advanced liver disease - Sihan Lin
• Astrocyte primary cilia regulate energy homeostasis   - Pierre Abiven
• Redefining weight loss : Increased energy expenditure to treat Obesity without significantly reducing food intake with CCT-217 Dual Gene Silencing. - Raj Reddy